Water-soluble Re6-clusters with aromatic phosphine ligands – from synthesis to potential biomedical applications

Record

  • Published inInorganic Chemistry Frontiers
  • Date
  • CitationIvanov A.A., Konovalov D.I., Pozmogova T.N., Solovieva A.O., Melnikov A.R., Brylev K.A., Kuratieva N.V., Yanshole V.V., Kirakci K., Lang K., Cheltygmasheva S.N., Kitamura N., Shestopalova L.V., Mironov Y.V., Shestopalov M.A. "Water-soluble Re6-clusters with aromatic phosphine ligands – from synthesis to potential biomedical applications" Inorg. Chem. Front. 2019. 6(4). P. 882-892. https://doi.org/10.1039/C8QI01216D
Paper BibTeX

Abstract

The development of water-soluble hexanuclear cluster complexes of low toxicity is a promising task due to their potential biomedical applications such as bioimaging and photodynamic therapy. Herein, we present the syntheses of two new water-soluble hexarhenium cluster complexes with terminal amphiphilic phosphine ligands, and delineate their photoluminescence and X-ray excited optical luminescence (XEOL) properties. These cluster complexes, namely [{Re6Q8}(PPh2CH2CH2COO)6]4− (Q = S (1); Se (2)), have the least cytotoxicity among all the tested hexanuclear metal-clusters, are capable of penetrating into cells and exhibit moderate photodynamic toxicity toward Hep-2 cells.